25 Apr

Herbert is a senior in the UHP, who was recently published.  The following post is written by him about what he did to get published:

I was selected to be a participant in the 2011 Summer Undergraduate Research Fellowship Program with the Department of Molecular Medicine at the University of Texas Health Science Center. I researched in the lab of Dr. P. Renee Yew. Specifically, we studied cyclin-dependent kinases (CDKs) and their inhibitors, both critical in the regulation of the cell cycle. We identified sites of phosphorylation on a particular CDK inhibitor (Xic2) found in the frog model Xenopus laevis. Phosphorylation at these sites serves to inhibit Xic2 degradation during interphase. We also elucidated a mechanism to show how Xic2 turnover occurs when DNA is first being replicated. Xic2 shares sequence homology with p21, a critical mammalian cell cycle regulator notably in response to DNA damage.

The paper was just published today on the website of Cell Division:
http://www.celldiv.com/content/8/1/5/abstract

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